Anemia is a lack of Red Blood Cells . One cause is a reduction in Vitamin B12 either as a lack in the diet or the inability to be absorbed.
Pernicious anemia is seen with persons taking proton pump inhibitors, Histamine blockers. Also may be seen with vegans, patients with Chron’s disease. Another group affected are those who have undergone a Whipple procedure surgery.
Upon examination, patients may demonstrate tongue changes such as atrophic glossitis. Hair may depigmentation. Neurological findings include posterior spinal chord abnormalities such as the inability to sense vibration and/or the inability to detect the location of the arms and legs. Leg spasticity and incontinence has been reported
Lab studies will demonstrate macrocytic anemia.
Treatment is cyanobalamin.